Publications

submenu

Recent Publications

Pregnancy-induced amelioration of muscular dystrophy phenotype in mdx mice via muscle membrane stabilization effect of glucocorticoid.
Shimizu-Motohashi Y, Asakura Y, Motohashi N, Belur NR, Baumrucker MG, Asakura A.
PLoS One. 2015 Mar 16;10(3):e0120325. doi: 10.1371/journal.pone.0120325. eCollection 2015. PMID:  25775477 

 

Risk Adjustment for Determining Surgical Site Infection in Colon Surgery: Are All Models Created Equal?
Muratore S, Statz C, Glover JJ, Kwaan M, Beilman G.
Surg Infect (Larchmt). 2015 Dec 4. [Epub ahead of print] PMID:26636274 

 

Extracorporeal membrane oxygenation credentialing: where do we stand? 
Muratore S, Beilman G, John R, Brunsvold M.
Am J Surg. 2015 Oct;210(4):655-60.e2. doi: 10.1016/j.amjsurg.2015.06.022. Epub 2015 Aug 20.  PMID:26384794 

 

Metabolic networks in a porcine model of trauma and hemorrhagic shock demonstrate different control mechanism with carbohydrate pre-feed.
Lusczek ER, Vincent T, Lexcen D, Kulkarni V, Mulier K, Beilman G.
BMC Emerg Med. 2015 Jul 1;15:13. doi: 10.1186/s12873-015-0038-1.  PMID:26130247 

 

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.
Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker HL, Boys CJ, Radke JP, Kroupina MG, Miller NC, Brearley AM, Zeisel SH, Georgieff MK.
Am J Clin Nutr. 2015 Nov;102(5):1113-25. doi: 10.3945/ajcn.114.099168. Epub 2015 Oct 7.  PMID: 26447156 

 

In adult twins, visceral fat accumulation depends more on exceeding sex-specific adiposity thresholds than on genetics.
Bosch TA, Chow L, Dengel DR, Melhorn SJ, Webb M, Yancey D, Callahan H, De Leon MR, Tyagi V, Schur EA. 
Metabolism. 2015 Sep;64(9):991-8. doi: 10.1016/j.metabol.2015.06.002. Epub 2015 Jun 6.  PMID: 26117000 

 

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.
Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM. 
J Mol Cell Cardiol. 2015 Aug;85:240-8. doi: 10.1016/j.yjmcc.2015.06.009. Epub 2015 Jun 16.  PMID: 26092277 

 

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F.
Nat Commun. 2015 Aug 6;6:7947. doi: 10.1038/ncomms8947.  PMID: 26245150    Free PMC Article 

 

Genotype-phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in the MPZ gene.
Sanmaneechai O, Feely S, Scherer SS, Herrmann DN, Burns J, Muntoni F, Li J, Siskind CE, Day JW, Laura M, Sumner CJ, Lloyd TE, Ramchandren S, Shy RR, Grider T, Bacon C, Finkel RS, Yum SW, Moroni I, Piscosquito G, Pareyson D, Reilly MM, Shy ME; Inherited Neuropathies Consortium - Rare Disease Clinical Research Consortium (INC-RDCRC).|
Brain. 2015 Nov;138(Pt 11):3180-92. doi: 10.1093/brain/awv241. Epub 2015 Aug 25.  PMID: 26310628 

 

MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.
Goodwin M, Mohan A, Batra R, Lee KY, Charizanis K, Gómez FJ, Eddarkaoui S, Sergeant N, Buée L, Kimura T, Clark HB, Dalton J, Takamura K, Weyn-Vanhentenryck SM, Zhang C, Reid T, Ranum LP, Day JW, Swanson MS. 
Cell Rep. 2015 Aug 18;12(7):1159-68. doi: 10.1016/j.celrep.2015.07.029. Epub 2015 Aug 6.  PMID: 26257173   Free Article 

 

Clinical phenotypes as predictors of the outcome of skipping around DMD exon 45.
Findlay AR, Wein N, Kaminoh Y, Taylor LE, Dunn DM, Mendell JR, King WM, Pestronk A, Florence JM, Mathews KD, Finkel RS, Swoboda KJ, Howard MT, Day JW, McDonald C, Nicolas A, Le Rumeur E, Weiss RB, Flanigan KM; United Dystrophinopathy Project. 
Ann Neurol. 2015 Apr;77(4):668-74. doi: 10.1002/ana.24365. Epub 2015 Mar 2.  PMID: 25612243 

 

Outcome reliability in non-ambulatory boys/men with Duchenne muscular dystrophy. 
Connolly AM, Malkus EC, Mendell JR, Flanigan KM, Miller JP, Schierbecker JR, Siener CA, Golumbek PT, Zaidman CM, Mcdonald CM, Johnson L, Nicorici A, Karachunski PI, Day JW, Kelecic JM, Lowes LP, Alfano LN, Darras BT, Kang PB, Quigley J, Pasternak AE, Florence JM; MDA DMD Clinical Research Network. 
Muscle Nerve. 2015 Apr;51(4):522-32. doi: 10.1002/mus.24346. Epub 2015 Feb 11.  PMID:  25056178 

 

Preliminary design of a new device to measure muscle function.
Lind J, Durfee W.
Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:5513-6. doi: 10.1109/EMBC.2015.7319640.  PMID:26737540 

 

Isometric skeletal muscle force measurement in primary myopathies.
Ginz HF, Iaizzo PA, Schweikert K, Durfee WK.
Muscle Nerve. 2015 Oct 27. doi: 10.1002/mus.24954. [Epub ahead of print] PMID:26506402 

 

Ipsilesional motor-evoked potential absence in pediatric hemiparesis impacts tracking accuracy of the less affected hand.
Cassidy JM, Carey JR, Lu C, Krach LE, Feyma T, Durfee WK, Gillick BT.
Res Dev Disabil. 2015 Dec;47:154-64. doi: 10.1016/j.ridd.2015.09.010. Epub 2015 Sep 29.  PMID:26426515 

 

Pax3-induced expansion enables the genetic correction of dystrophic satellite cells.
Filareto A, Rinaldi F, Arpke RW, Darabi R, Belanto JJ, Toso EA, Miller AZ, Ervasti JM, McIvor RS, Kyba M, Perlingeiro RC.
Skelet Muscle. 2015 Oct 26;5:36. doi: 10.1186/s13395-015-0061-7. eCollection 2015.  PMID: 26504514   Free PMC Article

 

Disease-proportional proteasomal degradation of missense dystrophins.
Talsness DM, Belanto JJ, Ervasti JM.
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12414-9. doi: 10.1073/pnas.1508755112. Epub 2015 Sep 21. PMID:26392559 

 

In vitro stability of therapeutically relevant, internally truncated dystrophins.
McCourt JL, Rhett KK, Jaeger MA, Belanto JJ, Talsness DM, Ervasti JM. 
Skelet Muscle. 2015 Apr 28;5:13. doi: 10.1186/s13395-015-0040-z. eCollection 2015. PMID: 25954502  Free PMC Article 

 

Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.
Narayanan P, Chatterton P, Ikeda A, Ikeda S, Corey DP, Ervasti JM, Perrin BJ. 
Nat Commun. 2015 Apr 21;6:6855. doi: 10.1038/ncomms7855.  PMID: 25897778   Free PMC Article 

 

Jejunal Interposition after Failed Esophageal Atresia Repair.
Bairdain S, Foker JE, Smithers CJ, Hamilton TE, Labow BI, Baird CW, Taghinia AH, Feins N, Manfredi M, Jennings RW.
J Am Coll Surg. 2015 Dec 13. pii: S1072-7515(15)01753-6. doi: 10.1016/j.jamcollsurg.2015.12.001. [Epub ahead of print] PMID:  26774491 

 

Foker process for the correction of long gap esophageal atresia: Primary treatment versus secondary treatment after prior esophageal surgery. 
Bairdain S, Hamilton TE, Smithers CJ, Manfredi M, Ngo P, Gallagher D, Zurakowski D, Foker JE, Jennings RW.
J Pediatr Surg. 2015 Jun;50(6):933-7. doi: 10.1016/j.jpedsurg.2015.03.010. Epub 2015 Mar 25. PMID:25841281 

 

Direct tracheobronchopexy to correct airway collapse due to severe tracheobronchomalacia: Short-term outcomes in a series of 20 patients.
Bairdain S, Smithers CJ, Hamilton TE, Zurakowski D, Rhein L, Foker JE, Baird C, Jennings RW.
J Pediatr Surg. 2015 Jun;50(6):972-7. doi: 10.1016/j.jpedsurg.2015.03.016. Epub 2015 Mar 14.  PMID:25824437 

 

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.
Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ. 
Cell Stem Cell. 2016 Feb 10. pii: S1934-5909(15)00546-9. doi: 10.1016/j.stem.2015.12.001. [Epub ahead of print]  PMID:  26877223 

 

Go to the Mattresses: A New Method for Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Maturation.
Garry MG, Garry DJ.
Circ Res. 2015 Dec 4;117(12):982-3. doi: 10.1161/CIRCRESAHA.115.307794. No abstract available.  PMID:  26635379 

 

The Etv2-miR-130a Network Regulates Mesodermal Specification.
Singh BN, Kawakami Y, Akiyama R, Rasmussen TL, Garry MG, Gong W, Das S, Shi X, Koyano-Nakagawa N, Garry DJ.
Cell Rep. 2015 Nov 3;13(5):915-23. doi: 10.1016/j.celrep.2015.09.060. Epub 2015 Oct 22.  PMID:  26565905   Free PMC Article 

 

Lift NIH restrictions on chimera research.
Sharma A, Sebastiano V, Scott CT, Magnus D, Koyano-Nakagawa N, Garry DJ, Witte ON, Nakauchi H, Wu JC, Weissman IL, Wu SM.
Science. 2015 Nov 6;350(6261):640. doi: 10.1126/science.350.6261.640-a. Epub 2015 Nov 5. No abstract available.  PMID:  26542560 

 

Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages.
Koyano-Nakagawa N, Shi X, Rasmussen TL, Das S, Walter CA, Garry DJ.
J Biol Chem. 2015 Nov 20;290(47):28107-19. doi: 10.1074/jbc.M115.662197. Epub 2015 Sep 22.  PMID:  26396195 

 

Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants.
Meyer AJ, Garry DJ, Hall B, Byrom MM, McDonald HG, Yang X, Yin YW, Ellington AD.
Nucleic Acids Res. 2015 Sep 3;43(15):7480-8. doi: 10.1093/nar/gkv734. Epub 2015 Jul 24. PMID:  26209133  Free PMC Article 

 

Hedgehog Signaling during Appendage Development and Regeneration. 
Singh BN, Koyano-Nakagawa N, Donaldson A, Weaver CV, Garry MG, Garry DJ. 
Genes (Basel). 2015 Jun 23;6(2):417-35. doi: 10.3390/genes6020417. Review.  PMID: 26110318   Free PMC Article 

 

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease.
Doyle MJ, Lohr JL, Chapman CS, Koyano-Nakagawa N, Garry MG, Garry DJ.
Stem Cell Rev. 2015 Oct;11(5):710-27. doi: 10.1007/s12015-015-9596-6.  PMID:  26085192 

 

Somatic Cell Therapy for Chronic Heart Failure: In Search of Mechanistic Insights. 
Garry GA, Garry DJ.
J Card Fail. 2015 Jul;21(7):583-5. doi: 10.1016/j.cardfail.2015.05.005. Epub 2015 May 15. No abstract available.  PMID:  25985791 

 

Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X.
J Biol Chem. 2015 Jun 12;290(24):15350-61. doi: 10.1074/jbc.M114.629956. Epub 2015 May 4.  PMID:  25940086

Cardiomyopathy in a dish: using human inducible pluripotent stem cells to model inherited cardiomyopathies.
Kamdar F, Klaassen Kamdar A, Koyano-Nakagawa N, Garry MG, Garry DJ.
J Card Fail. 2015 Sep;21(9):761-70. doi: 10.1016/j.cardfail.2015.04.010. Epub 2015 Apr 28. Review.  PMID:  25934595 

 

Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data.
Gong W, Koyano-Nakagawa N, Li T, Garry DJ.
BMC Bioinformatics. 2015 Mar 7;16:74. doi: 10.1186/s12859-015-0460-0.  PMID: 25887857   Free PMC Article 

 

The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.
Shi X, Zirbes KM, Rasmussen TL, Ferdous A, Garry MG, Koyano-Nakagawa N, Garry DJ.
J Biol Chem. 2015 Apr 10;290(15):9614-25. doi: 10.1074/jbc.M114.614628. Epub 2015 Feb 18.   PMID:  25694434  

 

The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. 
Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI.
ACS Chem Biol. 2015 Dec 16. [Epub ahead of print]  PMID:  26674547 

 

Regioselective C5-alkylation and C5-methylcarbamate formation of 2,3-dihydro-4-pyridones and C3-alkylation and C3-methylcarbamate formation of 4-(pyrrolidin-1-yl)furan-2(5H)-one.
Gu X, Georg GI.
Tetrahedron Lett. 2015 Oct 21;56(43):5874-5877.  PMID: 26663985 

 

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.
Patil S, Lis LG, Schumacher RJ, Norris BJ, Morgan ML, Cuellar RA, Blazar BR, Suryanarayanan R, Gurvich VJ, Georg GI. 
J Med Chem. 2015 Dec 10;58(23):9334-44. doi: 10.1021/acs.jmedchem.5b01329. Epub 2015 Nov 24.  PMID:  26596892   Free PMC Article 

 

Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions.
Li W, Schneider CM, Georg GI.
Org Lett. 2015 Aug 7;17(15):3902-5. doi: 10.1021/acs.orglett.5b01892. Epub 2015 Jul 15. PMID: 26176267 

 

Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies.
Siegel RA, Kapoor M, Cheryala N, Georg GI, Cloyd JC.
Epilepsy Behav. 2015 Aug;49:347-50. doi: 10.1016/j.yebeh.2015.05.004. Epub 2015 Jun 24.  PMID:  26115606 

 

Reformulating Tylocrebrine in Epidermal Growth Factor Receptor Targeted Polymeric Nanoparticles Improves Its Therapeutic Index.
Kirtane AR, Wong HL, Guru BR, Lis LG, Georg GI, Gurvich VJ, Panyam J.
Mol Pharm. 2015 Aug 3;12(8):2912-23. doi: 10.1021/acs.molpharmaceut.5b00173. Epub 2015 Jul 3.  PMID: 26065924   Free PMC Article 

 

Scalable syntheses of the BET bromodomain inhibitor JQ1.
Syeda SS, Jakkaraj S, Georg GI.
Tetrahedron Lett. 2015 Jun 3;56(23):3354-3457.  PMID:  26034331

 

A concise formal total synthesis of lactimidomycin.
Li W, Georg GI.
Chem Commun (Camb). 2015 May 21;51(41):8634-6. doi: 10.1039/c5cc02571k.  PMID:  25900419

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2.
Olesen SH, Ingles DJ, Zhu JY, Martin MP, Betzi S, Georg GI, Tash JS, Schönbrunn E.
Molecules. 2015 Jan 19;20(1):1643-60. doi: 10.3390/molecules20011643.   PMID:  25608045   Free PMC Article

Epigenetics: novel therapeutics targeting epigenetics.
Conway SJ, Woster PM, Shen JK, Georg G, Wang S.
J Med Chem. 2015 Jan 22;58(2):523-4. doi: 10.1021/jm501941q. Epub 2014 Dec 22. No abstract available.  PMID:  25532017 

 

Visualization of catheter ablation for atrial fibrillation: Impact of devices and anatomy.
Benscoter MA, Iaizzo PA.
World J Cardiol. 2015 Nov 26;7(11):754-64. doi: 10.4330/wjc.v7.i11.754. Review.   PMID:  26635923   Free PMC Article 

 

Isometric skeletal muscle force measurement in primary myopathies.
Ginz HF, Iaizzo PA, Schweikert K, Durfee WK. 
Muscle Nerve. 2015 Oct 27. doi: 10.1002/mus.24954. [Epub ahead of print]  PMID:  26506402 

 

Bears Show a Physiological but Limited Behavioral Response to Unmanned Aerial Vehicles.
Ditmer MA, Vincent JB, Werden LK, Tanner JC, Laske TG, Iaizzo PA, Garshelis DL, Fieberg JR.
Curr Biol. 2015 Aug 31;25(17):2278-83. doi: 10.1016/j.cub.2015.07.024. Epub 2015 Aug 13.   PMID:  26279232 

 

MRI Reconstructions of Human Phrenic Nerve Anatomy and Computational Modeling of Cryoballoon Ablative Therapy.
Goff RP, Spencer JH, Iaizzo PA.
Ann Biomed Eng. 2015 Jul 14. [Epub ahead of print]  PMID:  26168718

Coronary bifurcations as you have never seen them: the Visible Heart® Laboratory bifurcation programme.
Burzotta F, Cook B, Iaizzo PA, Singh J, Louvard Y, Latib A.
EuroIntervention. 2015;11 Suppl V:V40-3. doi: 10.4244/EIJV11SVA9.   PMID:  25983169  Free Article 

 

The Recovery of Hibernating Hearts Lies on a Spectrum: from Bears in Nature to Patients with Coronary Artery Disease.
Colbert RW, Holley CT, Stone LH, Crampton M, Adabag S, Garcia S, Iaizzo PA, Ward HB, Kelly RF, McFalls EO.
J Cardiovasc Transl Res. 2015 Jun;8(4):244-52. doi: 10.1007/s12265-015-9625-5. Epub 2015 May 7.  PMID:25946989 

 

Left phrenic nerve anatomy relative to the coronary venous system: Implications for phrenic nerve stimulation during cardiac resynchronization therapy. 
Spencer JH, Goff RP, Iaizzo PA. 
Clin Anat. 2015 Jul;28(5):621-6. doi: 10.1002/ca.22537. Epub 2015 Apr 8.   PMID:25851773 

 

Tissue properties of the fossa ovalis as they relate to transseptal punctures: a translational approach.
Howard SA, Quallich SG, Benscoter MA, Holmgren BC, Rolfes CD, Iaizzo PA.
J Interv Cardiol. 2015 Feb;28(1):98-108. doi: 10.1111/joic.12174.   PMID:25689553 

 

PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy.
Kang C, Ji LL.
Free Radic Biol Med. 2015 Dec 30;93:32-40. doi: 10.1016/j.freeradbiomed.2015.12.032. [Epub ahead of print]  PMID:  26746585

Redox signaling in skeletal muscle: role of aging and exercise.
Ji LL.
Adv Physiol Educ. 2015 Dec;39(4):352-9. doi: 10.1152/advan.00106.2014.   PMID:  26628659   Free Article 

 

[Development of Researches on Mechanisms of Acupoint Combination for Some Disorders in Nerve-humoral-immunological Modulation].
Long XQ, Jiang HL, Ren XJ, Ji LL, Tu Y.
Zhen Ci Yan Jiu. 2015 Aug;40(4):314-8. Review. Chinese.   PMID:  26502547 

 

Far upstream element-binding protein 1 (FUBP1) is a potential c-Myc regulator in esophageal squamous cell carcinoma (ESCC) and its expression promotes ESCC progression.
Yang L, Zhu JY, Zhang JG, Bao BJ, Guan CQ, Yang XJ, Liu YH, Huang YJ, Ni RZ, Ji LL. 
Tumour Biol. 2015 Oct 21. [Epub ahead of print]  PMID:  26490982.

 

Avenanthramide supplementation attenuates eccentric exercise-inflicted blood inflammatory markers in women. 
Koenig RT, Dickman JR, Kang CH, Zhang T, Chu YF, Ji LL.
Eur J Appl Physiol. 2016 Jan;116(1):67-76. doi: 10.1007/s00421-015-3244-3. Epub 2015 Aug 20.   PMID:  26289619 

 

Outcome reliability in non-ambulatory boys/men with Duchenne muscular dystrophy.
Connolly AM, Malkus EC, Mendell JR, Flanigan KM, Miller JP, Schierbecker JR, Siener CA, Golumbek PT, Zaidman CM, Mcdonald CM, Johnson L, Nicorici A, Karachunski PI, Day JW, Kelecic JM, Lowes LP, Alfano LN, Darras BT, Kang PB, Quigley J, Pasternak AE, Florence JM; MDA DMD Clinical Research Network.
Muscle Nerve. 2015 Apr;51(4):522-32. doi: 10.1002/mus.24346. Epub 2015 Feb 11.  PMID:  25056178 

 

Erratum: Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. 
Karim CB, Michel Espinoza-Fonseca L, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. 
Sci Rep. 2015 Oct 29;5:15872. doi: 10.1038/srep15872. No abstract available. PMID:  26513659   Free PMC Article 

 

Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. 
Karim CB, Espinoza-Fonseca LM, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. 
Sci Rep. 2015 Sep 28;5:14557. doi: 10.1038/srep14557.  PMID:  26411306   Free PMC Article 

 

GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T.
Exp Hematol. 2016 Jan;44(1):68-74.e10. doi: 10.1016/j.exphem.2015.09.007. Epub 2015 Oct 23.   PMID: 26477526 

 

Drosophila Cyclin G and epigenetic maintenance of gene expression during development. 
Dupont CA, Dardalhon-Cuménal D, Kyba M, Brock HW, Randsholt NB, Peronnet F.
Epigenetics Chromatin. 2015 May 7;8:18. doi: 10.1186/s13072-015-0008-6. eCollection 2015.   PMID:  25995770   Free PMC Article 

 

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. 
Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ. 
J Clin Invest. 2015 Jun;125(6):2369-74. doi: 10.1172/JCI77670. Epub 2015 May 11.  PMID:  25961454   Free PMC Article 

 

Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast. 
Zhang L, Guo J, Zhang P, Xiong Q, Wu SC, Xia L, Roy SS, Tolar J, O'Connell TD, Kyba M, Liao K, Zhang J. 
Circ Heart Fail. 2015 Jan;8(1):156-66. doi: 10.1161/CIRCHEARTFAILURE.114.001317. Epub 2014 Nov 24.  PMID:  25420485   Free PMC Article 

 

Portrait of the Master Genetic Counselor Clinician: A Qualitative Investigation of Expertise in Genetic Counseling. 
Miranda C, Veach PM, Martyr MA, LeRoy BS.
J Genet Couns. 2015 Aug 16. [Epub ahead of print]  PMID:  26275666 

 

Defining Our Clinical Practice: The Identification of Genetic Counseling Outcomes Utilizing the Reciprocal Engagement Model. 
Redlinger-Grosse K, Veach PM, Cohen S, LeRoy BS, MacFarlane IM, Zierhut H. 
J Genet Couns. 2015 Jul 25. [Epub ahead of print]  PMID:  26204965 

 

Diffusion MRI and its Role in Neuropsychology. 
Mueller BA, Lim KO, Hemmy L, Camchong J.
Neuropsychol Rev. 2015 Sep;25(3):250-71. doi: 10.1007/s11065-015-9291-z. Epub 2015 Aug 9.  PMID: 26255305

Longitudinal changes in white matter microstructure after heavy cannabis use. 
Becker MP, Collins PF, Lim KO, Muetzel RL, Luciana M.
Dev Cogn Neurosci. 2015 Dec;16:23-35. doi: 10.1016/j.dcn.2015.10.004. Epub 2015 Oct 9.  PMID:  26602958   Free Article 

 

Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo. 
Houang EM, Haman KJ, Filareto A, Perlingeiro RC, Bates FS, Lowe DA, Metzger JM. 
Mol Ther Methods Clin Dev. 2015 Nov 11;2:15042. doi: 10.1038/mtm.2015.42. eCollection 2015.  PMID:  26623440   Free PMC Article 

 

The myosin super-relaxed state is disrupted by estradiol deficiency. 
Colson BA, Petersen KJ, Collins BC, Lowe DA, Thomas DD.
Biochem Biophys Res Commun. 2015 Jan 2;456(1):151-5. doi: 10.1016/j.bbrc.2014.11.050. Epub 2014 Nov 21. PMID: 25446114   Free PMC Article 

 

Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments.
Librado P, Der Sarkissian C, Ermini L, Schubert M, Jónsson H, Albrechtsen A, Fumagalli M, Yang MA, Gamba C, Seguin-Orlando A, Mortensen CD, Petersen B, Hoover CA, Lorente-Galdos B, Nedoluzhko A, Boulygina E, Tsygankova S, Neuditschko M, Jagannathan V, Thèves C, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, Sicheritz-Ponten T, Popov R, Grigoriev S, Alekseev AN, Rubin EM, McCue M, Rieder S, Leeb T, Tikhonov A, Crubézy E, Slatkin M, Marques-Bonet T, Nielsen R, Willerslev E, Kantanen J, Prokhortchouk E, Orlando L. 
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6889-97. doi: 10.1073/pnas.1513696112. Epub 2015 Nov 23.  PMID:  26598656  Free PMC Article 

 

Evolutionary Genomics and Conservation of the Endangered Przewalski's Horse. 
Der Sarkissian C, Ermini L, Schubert M, Yang MA, Librado P, Fumagalli M, Jónsson H, Bar-Gal GK, Albrechtsen A, Vieira FG, Petersen B, Ginolhac A, Seguin-Orlando A, Magnussen K, Fages A, Gamba C, Lorente-Galdos B, Polani S, Steiner C, Neuditschko M, Jagannathan V, Feh C, Greenblatt CL, Ludwig A, Abramson NI, Zimmermann W, Schafberg R, Tikhonov A, Sicheritz-Ponten T, Willerslev E, Marques-Bonet T, Ryder OA, McCue M, Rieder S, Leeb T, Slatkin M, Orlando L.  
Curr Biol. 2015 Oct 5;25(19):2577-83. doi: 10.1016/j.cub.2015.08.032. Epub 2015 Sep 24.    PMID:  26412128 

 

Genome-wide SNP data show little differentiation between the Appaloosa and other American stock horse breeds.
Petersen JL, Mickelson JR, Valberg SJ, McCue ME. 
Anim Genet. 2015 Oct;46(5):585-6. doi: 10.1111/age.12301. Epub 2015 May 22. No abstract available.   PMID:  25997467 

 

Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis. 
McDonald AA, Hebert SL, McLoon LK. 
Neuromuscul Disord. 2015 Nov;25(11):873-87. doi: 10.1016/j.nmd.2015.09.001. Epub 2015 Sep 6.   PMID: 26429098 

 

Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.
Willoughby CL, Fleuriet J, Walton MM, Mustari MJ, McLoon LK.
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3484-96. doi: 10.1167/iovs.15-16761.  PMID:  26030103  Free PMC Article 

 

Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates. 
Willoughby CL, Fleuriet J, Walton MM, Mustari MJ, McLoon LK.  
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3467-83. doi: 10.1167/iovs.15-16852.   PMID:  26030102   Free PMC Article 

 

Disease course in mdx:utrophin+/- mice: comparison of three mouse models of Duchenne muscular dystrophy. 
McDonald AA, Hebert SL, Kunz MD, Ralles SJ, McLoon LK. 
Physiol Rep. 2015 Apr;3(4). pii: e12391. doi: 10.14814/phy2.12391.  PMID: 25921779   Free PMC Article 

 

C57BL/6 life span study: age-related declines in muscle power production and contractile velocity. 
Graber TG, Kim JH, Grange RW, McLoon LK, Thompson LV. 
Age (Dordr). 2015 Jun;37(3):9773. doi: 10.1007/s11357-015-9773-1. Epub 2015 Apr 17.  PMID:  25893911  Free PMC Article 

 

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy.
Duan D, Rafael-Fortney JA, Blain A, Kass DA, McNally EM, Metzger JM, Spurney CF, Kinnett K. 
J Cardiovasc Transl Res. 2015 Dec 30. [Epub ahead of print]    PMID:  26718928 

 

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.
Bedada FB, Wheelwright M, Metzger JM. 
Biochim Biophys Acta. 2015 Nov 11. pii: S0167-4889(15)00381-X. doi: 10.1016/j.bbamcr.2015.11.005. [Epub ahead of print] Review. PMID:  26578113   Free Article 

 

APSselect: Year One a Success!
Metzger JM, Samuelson LC. 
Physiologist. 2015 Jul;58(4):188-90. No abstract available. PMID:  26434156 

 

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment.
Barnabei MS, Sjaastad FV, Townsend D, Bedada FB, Metzger JM.
Sci Transl Med. 2015 Jul 1;7(294):294ra106. doi: 10.1126/scitranslmed.aaa4804.  PMID: 26136477 

 

The genetics of skeletal muscle disorders in horses.
Mickelson JR, Valberg SJ.
Annu Rev Anim Biosci. 2015;3:197-217. doi: 10.1146/annurev-animal-022114-110653. Epub 2014 Sep 12. Review.   PMID:  25387114 

 

Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.
Dell'Orco JM, Wasserman AH, Chopra R, Ingram MA, Hu YS, Singh V, Wulff H, Opal P, Orr HT, Shakkottai VG.
J Neurosci. 2015 Aug 12;35(32):11292-307. doi: 10.1523/JNEUROSCI.1357-15.2015.   PMID:  26269637  Free PMC Article 

 

A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1.
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY.
Elife. 2015 May 19;4. doi: 10.7554/eLife.07558.   PMID: 25988806  Free PMC Article 

 

Coaxing stem cells for skeletal muscle repair. 
McCullagh KJ, Perlingeiro RC.
Adv Drug Deliv Rev. 2015 Apr;84:198-207. doi: 10.1016/j.addr.2014.07.007. Epub 2014 Jul 15. Review.   PMID: 25049085 

 

Measuring quality of life in muscular dystrophy.
Bann CM, Abresch RT, Biesecker B, Conway KC, Heatwole C, Peay H, Scal P, Strober J, Uzark K, Wolff J, Margolis M, Blackwell A, Street N, Montesanti A, Bolen J.
Neurology. 2015 Mar 10;84(10):1034-42. doi: 10.1212/WNL.0000000000001336. Epub 2015 Feb 6.    PMID:  25663223 

 

Improving Health Care Transition Services: Just Grow Up, Will You Please.
Scal P. 
JAMA Pediatr. 2015 Nov 30:1-2. doi: 10.1001/jamapediatrics.2015.3268. [Epub ahead of print] No abstract available.   PMID:  26618900 

 

The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
Muretta JM, Jun Y, Gross SP, Major J, Thomas DD, Rosenfeld SS.
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6606-13. doi: 10.1073/pnas.1512305112. Epub 2015 Nov 16.     PMID:  26627252 

 

Direct real-time detection of the structural and biochemical events in the myosin power stroke.
Muretta JM, Rohde JA, Johnsrud DO, Cornea S, Thomas DD.
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14272-7. doi: 10.1073/pnas.1514859112. Epub 2015 Nov 2.   PMID:  26578772 

 

Voluntary Aerobic Exercise Reverses Frailty in Old Mice.
Graber TG, Ferguson-Stegall L, Liu H, Thompson LV. 
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1045-58. doi: 10.1093/gerona/glu163. Epub 2014 Sep 30.    PMID:  25271307 

 

Selective Localization of Myosin-I Proteins in Macropinosomes and Actin Waves.
Brzeska H, Koech H, Pridham KJ, Korn ED, Titus MA.
Cytoskeleton (Hoboken). 2016 Jan 23. doi: 10.1002/cm.21275. [Epub ahead of print]    PMID:  26801966

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases.
Osborn MJ, Webber BR, Knipping F, Lonetree CL, Tennis N, DeFeo AP, McElroy AN, Starker CG, Lee C, Merkel S, Lund TC, Kelly-Spratt KS, Jensen MC, Voytas DF, von Kalle C, Schmidt M, Gabriel R, Hippen KL, Miller JS, Scharenberg AM, Tolar J, Blazar BR.
Mol Ther. 2015 Oct 27. doi: 10.1038/mt.2015.197. [Epub ahead of print]   PMID:  26502778 

 

Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology.
Poynter JN, Bestrashniy JR, Silverstein KA, Hooten AJ, Lees C, Ross JA, Tolar J.
BMC Cancer. 2015 Oct 23;15:769. doi: 10.1186/s12885-015-1796-6.  PMID: 26497383  Free PMC Article 

 

GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T.
Exp Hematol. 2016 Jan;44(1):68-74.e10. doi: 10.1016/j.exphem.2015.09.007. Epub 2015 Oct 23.   PMID:  26477526 

 

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa. 
Watt SA, Dayal JH, Wright S, Riddle M, Pourreyron C, McMillan JR, Kimble RM, Prisco M, Gartner U, Warbrick E, McLean WH, Leigh IM, McGrath JA, Salas-Alanis JC, Tolar J, South AP.
PLoS One. 2015 Sep 18;10(9):e0137639. doi: 10.1371/journal.pone.0137639. eCollection 2015.  PMID:  26380979  Free PMC Article 

 

Hypoxia-induced cardiac injury in dystrophic mice.
Stelter Z, Strakova J, Yellamilli A, Fischer K, Sharpe K, Townsend D.
Am J Physiol Heart Circ Physiol. 2016 Feb 5:ajpheart.00917.2015. doi: 10.1152/ajpheart.00917.2015. [Epub ahead of print]    PMID:  26851247 

 

Diastolic dysfunction precedes hypoxia-induced mortality in dystrophic mice.
Townsend D.
Physiol Rep. 2015 Aug;3(8). pii: e12513. doi: 10.14814/phy2.12513.  PMID: 26311833   Free PMC Article 

 

Ca2+ ATPase Conformational Transitions in Lipid Bilayers Mapped by Site-directed Ethylation and Solid-State NMR. 
Vostrikov VV, Gustavsson M, Gopinath T, Mullen D, Dicke AA, Truong V, Veglia G.
ACS Chem Biol. 2015 Dec 18. [Epub ahead of print]    PMID:  26650884 

 

A tyrosine-tryptophan dyad and radical-based charge transfer in a ribonucleotide reductase-inspired maquette.
Pagba CV, McCaslin TG, Veglia G, Porcelli F, Yohannan J, Guo Z, McDaniel M, Barry BA. 
Nat Commun. 2015 Dec 2;6:10010. doi: 10.1038/ncomms10010.   PMID:  26627888   Free PMC Article 

 

A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement. 
Macchi Z, Wang Y, Moore D, Katz J, Saperstein D, Walk D, Simpson E, Genge A, Bertorini T, Fernandes JA, Swenson A, Elman L, Dimachkie M, Herbelin L, Miller J, Lu J, Wilkins H, Swerdlow RH, Statland J, Barohn R; Western ALS (WALS) Rasagiline Study Group. 
Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):345-52. doi: 10.3109/21678421.2015.1026826. Epub 2015 Apr 2.  PMID:  25832828  Free PMC Article  

 

Assay Interference by Chemical Reactivity.
Dahlin JL, Baell J, Walters MA. In: Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Iversen PW, Li Z, McGee J, McManus O, Minor L, Napper A, Peltier JM, Riss T, Trask OJ Jr., Weidner J, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. 2015 Sep 18.  PMID:  26561694  Free Books & Documents 

 

How to Triage PAINS-Full Research.
Dahlin JL, Walters MA.
Assay Drug Dev Technol. 2015 Oct 23. [Epub ahead of print]   PMID:  26496388 

 

Anemia management trends in patients on peritoneal dialysis in the past 10 years.
Liu H, Yao Y, Cao Y, Yang X, Huang B, Han X, Ren C.
Int J Clin Exp Med. 2015 Oct 15;8(10):18050-7. eCollection 2015.  PMID:  26770400 Free PMC Article 

 

Long-term outcomes after allogeneic hematopoietic stem cell transplantation for metachromatic leukodystrophy: the largest single-institution cohort report.
Boucher AA, Miller W, Shanley R, Ziegler R, Lund T, Raymond G, Orchard PJ.
Orphanet J Rare Dis. 2015 Aug 7;10:94. doi: 10.1186/s13023-015-0313-y.  PMID:  26245762   Free PMC Article

 

Enzyme replacement is associated with better cognitive outcomes after transplant in Hurler syndrome.
Eisengart JB, Rudser KD, Tolar J, Orchard PJ, Kivisto T, Ziegler RS, Whitley CB, Shapiro EG.
J Pediatr. 2013 Feb;162(2):375-80.e1. doi: 10.1016/j.jpeds.2012.07.052. Epub 2012 Sep 10.  PMID: 22974573  Free PMC Article